Resistance to enzymic degradation of LH-RH analogues possessing increased biological activity
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چکیده
منابع مشابه
3 H-labelling of a synthetic decapeptide having LH and FSH releasing activity (LH-RH--FSH-RH).
A decapeptide capable to stimulate the release of LH and FSH from pituitary has been recently isolated from hypothalami of porcine origin and its amino acid sequence has been established as (Pyro)Glu-HisTrp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH, [ 1,2]. An identical decapeptide has been found in sheep hypothalami [ 3,4] . Several laboratories described syntheses of LH-RH/FSH-RH either by the solid pha...
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BACKGROUND In Germany prostatic cancer is the most frequent cancer in men. The therapy of advanced prostatic cancer has changed significantly from the sub capsulate and / or total orchiectomy to the medical LH-RH analogues therapy during the last ten years, which has considerable effects on results and on costs. Both treatment procedures are based on a slowing down regulation of the growth of t...
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The mechanisms through which LH-RH antagonists suppress gonadotroph functions and LH-RH receptor (LH-RH-R) production are incompletely understood. To elucidate these mechanisms, we investigated the effects of Cetrorelix on the mRNA expression of pituitary LH-RH-R and luteinizing hormone (LH) secretion in three experimental systems with different pituitary LH-RH environments. Ovariectomy induced...
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ژورنال
عنوان ژورنال: Biochemical and Biophysical Research Communications
سال: 1977
ISSN: 0006-291X
DOI: 10.1016/0006-291x(77)90330-8